Familial clustering and genetic risk for dementia in a genetically isolated Dutch population

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Familial clustering and genetic risk for dementia in a genetically isolated Dutch population.

Despite advances in elucidating the genetic epidemiology of Alzheimer's disease and frontotemporal dementia, the aetiology for most patients with dementia remains unclear. We examined the genetic epidemiology of dementia in a recent genetically isolated Dutch population founded around 1750. The series of 191 patients ascertained comprised 122 probable Alzheimer's disease patients with late onse...

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Correction: Familial Aggregation between the 14th and 21st Century and Type 2 Diabetes Risk in an Isolated Dutch Population

Dr. Nanne Kleefstra should be listed as the third author, and Dr. Kleefstra’s affiliations are 1: Diabetes Centre, Isala, 8025 BT, Zwolle, The Netherlands, 5: Langerhans Medical Research Institute, Zwolle, The Netherlands, and 6: Department of Internal Medicine, University Medical Center Groningen and University of Groningen, 9700 RB, Groningen, The Netherlands. The contributions of this author...

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Familial Aggregation between the 14 and 21 Century and Type 2 Diabetes Risk in an Isolated Dutch Population

1 Diabetes Centre, Isala, 8025 BT, Zwolle, The Netherlands, 2 Department of General practice, University Medical Center Groningen and University of Groningen, 9700 RB, Groningen, The Netherlands, 3 General practice Urk, 8322 BA, The Netherlands, 4 Department of internal medicine, Gelre hospital, 7334 DZ, Apeldoorn, The Netherlands, 5 Langerhans Medical Research Institute, Zwolle, The Netherland...

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Familial Aggregation between the 14th and 21st Century and Type 2 Diabetes Risk in an Isolated Dutch Population

INTRODUCTION The development of type 2 diabetes results from an interaction of hereditary factors and environmental factors. This study aimed to investigate the contribution of interrelatedness to the risk of developing type 2 diabetes in an isolated Dutch population. MATERIALS AND METHODS A genealogical database from inhabitants living on the former island Urk between the 14th and 21st centu...

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ژورنال

عنوان ژورنال: Brain

سال: 2004

ISSN: 0006-8950,1460-2156

DOI: 10.1093/brain/awh179